ANAPC10 is a core component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase essential for controlling mitotic progression and G1 phase completion 1. The protein mediates ubiquitination and degradation of cell cycle regulators, primarily through formation of Lys-11-linked polyubiquitin chains, with secondary activity in Lys-48 and Lys-63-linked chain formation 1. ANAPC10 interacts directly with the APC/C inhibitor FBXO43 to regulate spermatogenesis, as demonstrated by loss-of-function mutations causing meiotic arrest in human male infertility 2. Clinically, ANAPC10 is significantly elevated in oral squamous cell carcinoma tissues, correlating with advanced disease stages, poor prognosis, and reduced overall survival 3. Elevated ANAPC10 expression promotes cancer cell proliferation, migration, and cell cycle progression while inhibiting apoptosis 3. ANAPC10 expression is regulated by aberrant epigenetic modifications, including H3K4me3 marks at its promoter in uveal melanoma pathogenesis 4. Beyond cancer, genetic variants in ANAPC10 associate with gut mycobiome composition and energy balance traits 56, expanding its roles beyond cell cycle regulation into broader metabolic and immunological processes.