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GeneE
26 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
ANG
angiogenin
Chromosome 14 Β· 14q11.2
NCBI Gene: 283Ensembl: ENSG00000214274.11HGNC: HGNC:483UniProt: P03950
240PubMed Papers
21Diseases
0Drugs
7Pathogenic Variants
CLINICAL
OMIM Disease Gene
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
angiogenesisreceptor ligand activityresponse to hypoxiapositive regulation of endothelial cell proliferationamyotrophic lateral sclerosistype 1 diabetes mellitusamyotrophic lateral sclerosis, dominantfrontotemporal dementia
✦AI Summary

The provided PubMed abstracts do not contain information about the ANG (angiogenin) gene. All abstracts discuss the renin-angiotensin system and angiopoietins, which are different molecular pathways unrelated to angiogenin function. The abstracts focus on angiotensin II-generating enzymes 1, angiopoietin-2 regulation of vascular smooth muscle cells 2, angiopoietin concentrations during faricimab treatment 3, angiopoietin-1 and VEGF in angiogenesis 4, the angiopoietin family and Tie2 receptor signaling 5, RAAS axis interactions with SARS-CoV-2 6, non-ACE pathway angiotensin II production 7, and angiotensin II type 1 receptor localization 8. None of these abstracts address angiogenin as a secreted ribonuclease, its role in tRNA cleavage, stress granule assembly, ribosomal RNA transcription, or its association with amyotrophic lateral sclerosis. Therefore, I cannot provide a gene function summary for ANG (angiogenin) based on the provided literature, as the abstracts discuss entirely different genes and pathways.

Sources cited
1
Discusses angiotensin II-generating enzymes, not angiogenin
PMID: 11173502
2
Covers angiopoietin-2 regulation of vascular smooth muscle cells, not angiogenin
PMID: 40028724
3
Examines angiopoietin concentrations during treatment, not angiogenin
PMID: 39723678
4
Focuses on angiopoietin-1 and VEGF in angiogenesis, not angiogenin
PMID: 38652215
5
Reviews angiopoietin family and Tie2 signaling, not angiogenin
PMID: 12783598
6
Discusses RAAS axis and SARS-CoV-2, not angiogenin
PMID: 36556919
7
Covers non-ACE pathway angiotensin II production, not angiogenin
PMID: 23176219
8
Studies angiotensin II type 1 receptor localization, not angiogenin
PMID: 33615887
Disease Associationsβ“˜21
amyotrophic lateral sclerosisOpen Targets
0.79Strong
type 1 diabetes mellitusOpen Targets
0.47Moderate
amyotrophic lateral sclerosis, dominantOpen Targets
0.37Weak
frontotemporal dementiaOpen Targets
0.26Weak
genetic disorderOpen Targets
0.19Weak
familial amyotrophic lateral sclerosisOpen Targets
0.12Weak
frontotemporal dementia with motor neuron diseaseOpen Targets
0.12Weak
neoplasmOpen Targets
0.09Suggestive
cancerOpen Targets
0.09Suggestive
hepatocellular carcinomaOpen Targets
0.09Suggestive
gliomaOpen Targets
0.08Suggestive
retinopathy of prematurityOpen Targets
0.08Suggestive
congestive heart failureOpen Targets
0.08Suggestive
dengue diseaseOpen Targets
0.08Suggestive
colon adenocarcinomaOpen Targets
0.06Suggestive
glioblastoma multiformeOpen Targets
0.06Suggestive
endometriosisOpen Targets
0.06Suggestive
Parkinson diseaseOpen Targets
0.06Suggestive
osteosarcomaOpen Targets
0.06Suggestive
prostate cancerOpen Targets
0.06Suggestive
Amyotrophic lateral sclerosis 9UniProt
Pathogenic Variants7
NM_001097577.3(ANG):c.155G>A (p.Ser52Asn)Likely pathogenic
Amyotrophic lateral sclerosis type 9
β˜…β˜†β˜†β˜†2022β†’ Residue 52
NM_001097577.3(ANG):c.409G>A (p.Val137Ile)Pathogenic
Amyotrophic lateral sclerosis type 9
β˜†β˜†β˜†β˜†2008β†’ Residue 137
NM_001097577.3(ANG):c.121A>G (p.Lys41Glu)Pathogenic
Amyotrophic lateral sclerosis type 9
β˜†β˜†β˜†β˜†2006β†’ Residue 41
NM_001097577.3(ANG):c.189C>G (p.Cys63Trp)Pathogenic
Amyotrophic lateral sclerosis type 9
β˜†β˜†β˜†β˜†2006β†’ Residue 63
NM_001097577.3(ANG):c.191A>T (p.Lys64Ile)Pathogenic
Amyotrophic lateral sclerosis type 9
β˜†β˜†β˜†β˜†2006β†’ Residue 64
NM_001097577.3(ANG):c.164G>A (p.Arg55Lys)Pathogenic
Amyotrophic lateral sclerosis type 9
β˜†β˜†β˜†β˜†2006β†’ Residue 55
NM_001097577.3(ANG):c.107A>T (p.Gln36Leu)Pathogenic
Amyotrophic lateral sclerosis type 9
β˜†β˜†β˜†β˜†2006β†’ Residue 36
View on ClinVar β†—
Related Genes
RNASE2Protein interaction100%RNASE4Protein interaction99%RNH1Protein interaction97%RNASE8Protein interaction90%RNASET2Protein interaction82%PLXNB2Protein interaction81%
Tissue Expression6 tissues
Liver
100%
Ovary
4%
Lung
1%
Heart
1%
Brain
0%
Bone Marrow
0%
Gene Interaction Network
Click a node to explore
ANGRNASE2RNASE4RNH1RNASE8RNASET2PLXNB2
PROTEIN STRUCTURE
Preparing viewer…
PDB4AOH Β· 1.04 Γ… Β· X-ray
View on RCSB β†—
Constraintβ“˜
LOEUFβ“˜
1.70LoF Tolerant
pLIβ“˜
0.42Tolerant
Observed/Expected LoF0.00 [0.00–1.70]
RankingsWhere ANG stands among ~20K protein-coding genes
  • #1,634of 20,598
    Most Researched240 Β· top 10%
  • #3,156of 5,498
    Most Pathogenic Variants7
  • #16,092of 17,882
    Most Constrained (LOEUF)1.70
Genes detectedANG
Sources retrieved26 papers
Response timeβ€”
πŸ“„ Sources
26β–Ό
1
Angiotensin II-generating enzymes.
PMID: 11173502
Biochemistry (Mosc) Β· 2000
1.00
2
Angiopoietin-2 regulates the phenotypic switch of vascular smooth muscle cells.
PMID: 40028724
FASEB J Β· 2025
0.90
3
Changes in Aqueous Angiopoietin-1/2 Concentrations During the Induction Phase of Intravitreal Faricimab Injections for Diabetic Macular Edema.
PMID: 39723678
Transl Vis Sci Technol Β· 2024
0.80
4
Ang-1 and VEGF: central regulators of angiogenesis.
PMID: 38652215
Mol Cell Biochem Β· 2025
0.70
5
[Angiotensin II receptor].
PMID: 14737832
Nihon Rinsho Β· 2004
0.68