ANKK1 (ankyrin repeat and kinase domain containing 1) is a serine/threonine RIP-family kinase located on chromosome 11 that functions as a scaffold protein in dopaminergic neurotransmission and neural development 1. The gene contains a kinase domain and 11 ankyrin repeats and is expressed exclusively in astrocytes within the central nervous system, with expression upregulated by dopaminergic agonists 2. ANKK1 serves as a Wnt/PCP scaffold protein that interacts with FARP1 and WGEF to regulate RhoGTPase activation and F-actin assembly during neuritogenesis and neuronal migration 3. It likely regulates DRD2 expression through NF-kappaB signaling 1. The TaqIA polymorphism (rs1800497) located in ANKK1 exon 8 has been extensively studied in psychiatric and neurological disorders. This variant shows association with attention deficit hyperactivity disorder (ADHD) in a dominant model (OR=1.785, p=0.027), particularly in African populations 4, and with migraine susceptibility 5. The polymorphism also influences impulsivity through gene-by-environment interactions with paternal maltreatment 6 and contributes to adolescent smoking risk through effects on striatal dopamine signaling 7. However, meta-analysis found no significant associations between ANKK1 polymorphisms and executive function domains in healthy adults 8.