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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
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ANKRD53
ankyrin repeat domain 53
Chromosome 2 Β· 2p13.3
NCBI Gene: 79998Ensembl: ENSG00000144031.12HGNC: HGNC:25691UniProt: C9JZ61
9PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingmitotic metaphase chromosome alignmentpositive regulation of microtubule polymerizationregulation of mitotic spindle organizationneurodegenerative diseasegastric adenocarcinomaesophageal ulcerobesity
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

ankyrin repeat domain 53

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
neurodegenerative diseaseOpen Targets
0.33Weak
gastric adenocarcinomaOpen Targets
0.03Suggestive
esophageal ulcerOpen Targets
0.02Suggestive
obesityOpen Targets
0.02Suggestive
neoplasmOpen Targets
0.01Suggestive
cancerOpen Targets
0.01Suggestive
colorectal cancerOpen Targets
0.01Suggestive
gastric cancerOpen Targets
0.00Suggestive
chromosome 16 trisomyOpen Targets
0.00Suggestive
gliomaOpen Targets
0.00Suggestive
metopic craniosynostosisOpen Targets
0.00Suggestive
clear cell renal carcinomaOpen Targets
0.00Suggestive
head and neck squamous cell carcinomaOpen Targets
0.00Suggestive
hepatocellular carcinomaOpen Targets
0.00Suggestive
lung cancerOpen Targets
0.00Suggestive
lymphomaOpen Targets
0.00Suggestive
ovarian serous cystadenocarcinomaOpen Targets
0.00Suggestive
thyroid cancer, nonmedullary, 1Open Targets
0.00Suggestive
Uterine CarcinosarcomaOpen Targets
0.00Suggestive
uterine corpus endometrial carcinomaOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
PSRC1Shared pathway50%MAP9Shared pathway25%DCDC1Shared pathway20%H3-7Shared pathway17%H3Y1Shared pathway17%H3Y2Shared pathway17%
Tissue Expression6 tissues
Ovary
100%
Brain
30%
Lung
23%
Bone Marrow
18%
Liver
15%
Heart
12%
Gene Interaction Network
Click a node to explore
ANKRD53PSRC1MAP9DCDC1H3-7H3Y1H3Y2
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q8N9V6
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.38LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF1.01 [0.74–1.38]
RankingsWhere ANKRD53 stands among ~20K protein-coding genes
  • #17,265of 20,598
    Most Researched9
  • #14,366of 17,882
    Most Constrained (LOEUF)1.38
Genes detectedANKRD53
Sources retrieved0 papers
Response timeβ€”