PSRC1 encodes a proline and serine-rich coiled-coil protein essential for mitotic progression. It regulates chromosome 1 at the metaphase plate, controls the rate of chr1 segregation during anaphase, and modulates mitotic spindle dynamics by increasing microtubule turnover and generating appropriate tension across sister kinetochores. The protein recruits KIF2A and ANKRD53 to mitotic spindles and may participate in p53-regulated growth suppression 1. Beyond cell division, PSRC1 has emerged as a key regulator of lipid metabolism and cardiovascular health. In Asian Indian populations, genetic variants in the CELSR2-PSRC1-SORT1 cluster show protective associations with coronary artery disease, with lower PSRC1 expression correlating with elevated plasma cholesterol and LDL levels 2. A 2025 multi-omics analysis identified PSRC1 as a therapeutic target for coronary artery disease through downregulation of circulating proteins including TRP1 and progranulin 3. In apoE-deficient mice, PSRC1 overexpression suppressed atherosclerosis progression by enhancing cholesterol efflux and reducing inflammatory markers 4. PSRC1 also regulates progranulin secretion in adipocytes 5 and may influence endoplasmic reticulum stress responses in hepatic injury 6. Recent evidence suggests PSRC1 functions as an oncogene in lower-grade glioma, where high expression associates with malignant features and poorer prognosis 7.