PSRC1 (proline and serine rich coiled-coil 1) is a multifunctional protein with primary roles in mitotic regulation and lipid metabolism. The protein is required for normal mitotic progression, specifically regulating chromosome 1 at the metaphase plate and chr1 segregation during anaphase 1. PSRC1 functions by modulating mitotic spindle dynamics, increasing microtubule turnover rates on metaphase spindles, and recruiting key proteins like KIF2A and ANKRD53 to spindle poles 1. Beyond cell division, PSRC1 plays a crucial role in cholesterol homeostasis and cardiovascular health. The protein enhances cholesterol efflux capacity in macrophages and inhibits foam cell formation by upregulating PPAR-γ and LXR-α expression 2. Clinical studies demonstrate that PSRC1 genetic variants are associated with plasma lipid levels and coronary artery disease risk in multiple populations 34. Lower PSRC1 expression correlates with increased CAD risk, while overexpression provides atheroprotective effects 2. The gene is also regulated by DNA methylation and transcription factors like YY1, with variants affecting progranulin secretion 56. Additionally, PSRC1 shows potential as a therapeutic target in lower-grade glioma and plays protective roles against hepatotoxicity through ER stress modulation 78.