CCSER2 is a microtubule-associated protein that functions as a plus-end-tracking protein (+TIP), localizing to the extending tips of microtubules in human cells 1. The protein contains two SxIP motifs in its C-terminal region that are important for microtubule tracking function, and it localizes primarily to peripheral regions of microtubule fibers where it likely functions in cell projections 1. Beyond microtubule dynamics, CCSER2 plays a critical regulatory role in dynein-mediated cargo trafficking by gating cytoplasmic dynein activity specifically at the cell periphery 2. It accomplishes this by inhibiting the interaction between dynein and its regulatory protein Ndel1 in a spatially localized manner, resulting in peripheral dynein activation that promotes cell migration 2. In cancer biology, CCSER2 has been identified as a prognostic biomarker in clear cell renal cell carcinoma (ccRCC), where it is expressed by tumor-infiltrated CD8+ T cells and associates with improved patient prognosis 3. Additionally, CCSER2 demonstrates stable expression in breast cancer and other cancer models, making it useful as a housekeeping gene for gene expression normalization studies 4, 5, though its suitability varies depending on experimental conditions and tissue context 6.