NCKAP5 (NCK associated protein 5) is a protein involved in microtubule dynamics and cytoskeletal organization, with established roles in microtubule bundle formation and depolymerization at plus-ends [GO annotations]. While its primary molecular functions relate to microtubule regulation, NCKAP5 has emerged as a biomarker with clinical significance across multiple cancer types. In non-small cell lung cancer (NSCLC), NCKAP5 expression is significantly downregulated compared to normal tissue, and experimental knockdown promotes cancer cell proliferation, suggesting a tumor suppressive role 1. The gene shows associations with immune cell infiltration patterns, being negatively correlated with regulatory T cells and naïve B cells but positively correlated with activated dendritic cells and natural killer cells 1. NCKAP5 variants have been identified as prognostic indicators in hereditary diffuse gastric cancer, where germline variants associate with poor overall survival 2. Additionally, NCKAP5 appears in gene signatures predictive of chemotherapy response in ERBB2-driven breast cancers 3 and shows differential expression in various disease contexts including vestibular schwannomas 4 and Type 1 diabetes mellitus comorbidities 5. These findings suggest NCKAP5 functions extend beyond cytoskeletal regulation to encompass roles in cancer biology and therapeutic response prediction.