STMN4 is a stathmin family member exhibiting microtubule-destabilizing activity through direct tubulin binding and sequestration 1. The protein localizes to the cytoplasm and regulates microtubule dynamics, supporting neuron projection development and neurophysiology 23. In neuroblastoma, STMN4 expression is consistently upregulated during differentiation induced by multiple pathways including 9-cis retinoic acid treatment and MYCN knockdown 45. Stable STMN4 expression alone promotes neuroblastoma cell differentiation, and higher tumor STMN4 mRNA levels correlate with improved progression-free survival in patients 4. Beyond neuroblastoma, STMN4 has broader pathological relevance. In glioblastoma, STMN4 is specifically upregulated in invasive tumor rim regions, suggesting association with tumor invasiveness 6. In colorectal cancer, STMN4 dysregulation is an independent prognostic factor for survival outcomes 7. Additionally, STMN4 has been identified as required for normal neurophysiology in Alzheimer disease risk gene screens, indicating CNS roles beyond differentiation control 23. Genetic variants near STMN4 show suggestive associations with restricted repetitive behaviors in autism spectrum disorder, though evidence requires further validation 8.