ANO6 (anoctamin 6) is a calcium-activated phospholipid scramblase and ion channel that mediates cell surface exposure of phosphatidylserine 1. Upon intracellular calcium elevation, ANO6 translocates phosphatidylserine from the inner to outer plasma membrane leaflet 2, a process critical for multiple pathological processes. ANO6 regulates ADAM17 sheddase activity and metalloproteinase function by facilitating phosphatidylserine externalization 2. During SARS-CoV-2 infection, ANO6-mediated phosphatidylserine scrambling is essential for viral entry and syncytia formation, making ANO6 inhibition a potential therapeutic strategy 3. In cancer, ANO6 is highly expressed in multiple tumor types and associated with poor prognosis 4. Notably, in breast cancer, ANO6 expression correlates with macrophage polarization, immune infiltration, and tumor stromal pathways 5. In tumor-lipid-associated macrophage fusion cells, ANO6 is stabilized by SNX10 through the CBX3-SNX10-ANO6 axis, promoting metastatic progression and lipid accumulation 6. In Alzheimer's disease, ANO6 targets TMEM30A to regulate endoplasmic reticulum stress-induced ferroptosis and neuronal injury 7. These findings position ANO6 as a pleiotropic regulator relevant to cancer progression, viral infection, and neurodegeneration.