ATP10A is a catalytic component of P4-ATPase flippase complexes that primarily translocates phosphatidylcholine (PC) from the outer to inner leaflet of the plasma membrane in an ATP-dependent manner 1. The protein requires CDC50A for proper localization to the plasma membrane 1. Beyond its canonical PC-flipping function, ATP10A can also translocate phosphatidylinositol, contributing to phosphoinositide homeostasis at the plasma membrane 2. Functionally, ATP10A initiates inward plasma membrane bending and recruits BAR domain-containing proteins involved in membrane tubulation and trafficking 3. It facilitates beta1 integrin endocytosis, delaying cell adhesion and spreading on extracellular matrix 1. The enzyme has low activity toward glucosylceramide 4. Clinically, ATP10A downregulation occurs in cerebrovascular endothelial cells in Alzheimer's disease 5, and the gene is enriched in dendritic cells expressing eosinophilic esophagitis risk alleles 6. In humans, ATP10A exhibits variable monoallelic and biallelic expression in brain tissue, influenced by gender and genetic polymorphisms rather than classical imprinting mechanisms 7.