BORCS6 is a subunit of the BLOC-1-related complex (BORC) that localizes to the cytosolic face of lysosomes and regulates lysosomal positioning and transport. As part of the BORC complex, BORCS6 recruits the ARL8B GTPase to lysosomes, coupling them to kinesin-based microtubule plus-end-directed transport for anterograde movement toward the cell periphery 1. Beyond canonical lysosomal trafficking, BORCS6 plays important roles in immune and metabolic homeostasis. Cold exposure induces BORCS6 expression in human CD4+ T cells, where it suppresses mTOR signaling at lysosomal surfaces, thereby promoting regulatory T cell differentiation and supporting adipose tissue anti-inflammatory responses 2. In pulmonary biology, BORCS6 maintains normal lamellar body morphology in alveolar epithelial cells; BORCS6 knockout or loss of its regulator LRRK2 causes lamellar body enlargement and impaired surfactant secretion, suggesting BORCS6 dysfunction compromises lung homeostasis 3. Additionally, SARS-CoV-2 ORF3a protein hijacks BORCS6 to promote anterograde lysosomal transport of viral particles to the plasma membrane for efficient egress 1. These findings position BORCS6 as a critical regulator of lysosomal-microtubule dynamics with consequences for metabolism, immunity, lung function, and viral pathogenesis.