BORCS7 is a subunit of the BLOC-1 related complex (BORC), a cytosolic protein complex that regulates lysosomal positioning and organelle transport. As part of BORC, BORCS7 associates with the cytosolic face of lysosomes and facilitates recruitment of the ARL8B GTPase to couple lysosomes to kinesin motors for microtubule plus-end-directed transport 1. This positions lysosomes at the cell periphery and regulates endosome and lysosome size through organelle-cytoskeleton interactions 1. Genetically, BORCS7 is a schizophrenia risk gene at the chromosome 10.32 locus. Risk alleles increase BORCS7 expression in the human brain, particularly in neurons and astrocytes during development 23. Structural variations affecting BORCS7 expression contribute to schizophrenia susceptibility, and mice overexpressing Borcs7 in the medial prefrontal cortex exhibit schizophrenia-like behaviors including abnormal prepulse inhibition and social dysfunction 4. BORCS7 also negatively regulates muscle mass and function, as genetic variants reducing BORCS7 expression causally associate with improved muscle quantity and quality, suggesting therapeutic potential for sarcopenia treatment 5. Additionally, BORCS7 expression is modulated during human cytomegalovirus infection 6.