KXD1 (KxDL motif containing 1) is a BORC complex component that regulates lysosome positioning and transport. As part of the BORC complex, KXD1 associates with the cytosolic face of lysosomes and recruits ARL8B to couple lysosomes to microtubule plus-end-directed kinesin motors, facilitating lysosome movement toward the cell periphery 1. KXD1 also interacts with BLOS1, a shared subunit of BLOC-1 and BORC complexes involved in lysosomal trafficking and biogenesis of lysosome-related organelles such as melanosomes 2. KXD1 plays a critical role in pathogen-host interactions. The autophagy-resistant Mycobacterium tuberculosis Beijing strain upregulates KXD1 expression to suppress lysosome repositioning toward the perinuclear region and block lysosomal delivery to mycobacterial phagosomes during starvation-induced autophagy, enabling intracellular bacterial survival 34. Depletion of KXD1 and its partner Plekhm2 reverses this autophagy evasion, restoring lysosomal delivery and restricting bacterial survival. Clinically, KXD1 emerged as a candidate immunotherapy target in a pan-cancer stemness signature predictive of immunotherapy response 5. Additionally, changes in KXD1 expression were associated with improved response to nortriptyline antidepressant treatment 6. These findings suggest KXD1's broader involvement in cellular responses beyond lysosomal function.