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GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
BRICD5
BRICHOS domain containing 5
Chromosome 16 Β· 16p13.3
NCBI Gene: 283870Ensembl: ENSG00000182685.8HGNC: HGNC:28309UniProt: Q6PL45
8PubMed Papers
16Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingregulation of cell population proliferationGO:0005615membranemetabolic syndromeAbnormality of the skeletal systemasthmapachyonychia congenita
✦AI Summary

Based on limited published evidence, BRICD5 (BRICHOS domain containing 5) is a protein-binding molecule located on chromosome 16. UniProt annotations indicate roles in protein binding and regulation of cell population proliferation. BRICD5 was identified in an epigenome-wide association study as a differentially methylated region associated with lung cancer risk in pre-diagnostic blood samples 1, though the authors note causality remains to be established. Specific molecular mechanisms and cellular functions require further investigation.

Sources cited
1
BRICD5 identified as a differentially methylated region significantly associated with lung cancer risk in pre-diagnostic peripheral blood samples
PMID: 34008478
⚠Limited data available β€” This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsβ“˜16
metabolic syndromeOpen Targets
0.07Suggestive
Abnormality of the skeletal systemOpen Targets
0.06Suggestive
asthmaOpen Targets
0.01Suggestive
pachyonychia congenitaOpen Targets
0.00Suggestive
visceral LeishmaniasisOpen Targets
0.00Suggestive
clear cell renal carcinomaOpen Targets
0.00Suggestive
diffuse large B-cell lymphomaOpen Targets
0.00Suggestive
head and neck squamous cell carcinomaOpen Targets
0.00Suggestive
Hereditary breast cancerOpen Targets
0.00Suggestive
hereditary breast carcinomaOpen Targets
0.00Suggestive
lung cancerOpen Targets
0.00Suggestive
sarcomaOpen Targets
0.00Suggestive
thyroid cancer, nonmedullary, 1Open Targets
0.00Suggestive
Uterine CarcinosarcomaOpen Targets
0.00Suggestive
uterine corpus endometrial carcinomaOpen Targets
0.00Suggestive
Uveal MelanomaOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
TFAP2DShared pathway100%CDCA7Shared pathway100%GKN2Shared pathway100%TFAP2EShared pathway100%TRAPPC14Shared pathway50%NACC1Shared pathway50%
Tissue Expression6 tissues
Lung
100%
Liver
87%
Ovary
79%
Bone Marrow
60%
Heart
44%
Brain
19%
Gene Interaction Network
Click a node to explore
BRICD5TFAP2DCDCA7GKN2TFAP2ETRAPPC14NACC1
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted Β· UniProt Q6PL45
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.98LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF1.87 [1.45–1.98]
RankingsWhere BRICD5 stands among ~20K protein-coding genes
  • #17,542of 20,598
    Most Researched8
  • #17,813of 17,882
    Most Constrained (LOEUF)1.98
Genes detectedBRICD5
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
Epigenome-wide scan identifies differentially methylated regions for lung cancer using pre-diagnostic peripheral blood.
PMID: 34008478
Epigenetics Β· 2022
1.00