1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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24PubMed Papers
21Diseases
0Drugs
1Pathogenic Variants
CLINICALOMIM Disease Gene
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingalpha-tubulin bindingregulation of cell population proliferationcilium assemblyautosomal recessive primary microcephalymicrocephaly 25, primary, autosomal recessivehepatocellular carcinomaneoplasm
Based on limited published evidence, TRAPPC14 is a specific subunit of the TRAPP II complex, a conserved vesicle tethering machinery involved in late Golgi trafficking 12. TRAPPC14 is dispensable for TRAPP II complex structural integrity but specifically mediates preciliary vesicle tethering to the mother centriole during ciliogenesis by linking TRAPP II to Rabin8 2. The protein also modulates YAP1 transcriptional activity 3. Mutations cause autosomal recessive primary microcephaly 25, suggesting critical roles in cell division and neural development.
1
TRAPPC14 mediates Rabin8-TRAPP II association and preciliary vesicle tethering at the mother centriole during ciliogenesis
PMID: 314670832
TRAPP II complex functions as a membrane tether in late Golgi trafficking
PMID: 307151793
TRAPPC14 modulates YAP1 activity as a transcriptional regulator
PMID: 30447097⚠Limited data available — This gene has 3 indexed publications. Summary and analysis may be incomplete.
autosomal recessive primary microcephalyOpen Targets
microcephaly 25, primary, autosomal recessiveOpen Targets
hepatocellular carcinomaOpen Targets
Alzheimer diseaseOpen Targets
cirrhosis of liverOpen Targets
acute lymphoblastic leukemiaOpen Targets
Neurodevelopmental disorderOpen Targets
non-Hodgkins lymphomaOpen Targets
pancreatic ductal adenocarcinomaOpen Targets
Primary microcephalyOpen Targets
gastric cancerOpen Targets
head and neck squamous cell carcinomaOpen Targets
hereditary breast carcinomaOpen Targets
ovarian serous cystadenocarcinomaOpen Targets
pancreatic adenocarcinomaOpen Targets
thyroid cancer, nonmedullary, 1Open Targets
Microcephaly 25, primary, autosomal recessiveUniProt
NM_018275.5(TRAPPC14):c.613G>T (p.Glu205Ter)Pathogenic
Microcephaly 25, primary, autosomal recessive
☆☆☆☆2023→ Residue 205