BRINP2 is a neurodevelopmental protein that functions as a negative regulator of neuronal cell cycle progression. During nervous system development, BRINP2 is induced by bone morphogenetic protein (BMP) and retinoic acid signaling, with expression beginning at embryonic stage E11.5 and localizing to specific brain regions in a spatiotemporally regulated manner 1. When expressed in nonneuronal cells, BRINP2 suppresses cell cycle progression 1, consistent with its role in promoting postmitotic neuron differentiation. BRINP2 belongs to the Membrane Attack Complex/Perforin (MACPF) superfamily and is highly conserved across vertebrate species 23. Genetically, BRINP2 dysfunction has been implicated in neurodevelopmental disorders. Brinp2 knockout mice exhibit hyperactivity and are associated with genetic variation at the chromosome 1.2 locus implicated in attention deficit hyperactivity disorder (ADHD) 4. Beyond neurodevelopmental pathology, BRINP2 has been identified as a novel prognostic biomarker for pancreatic adenocarcinoma, correlating with tumor immune microenvironment characteristics 5. Additionally, BRINP2 is upregulated in Long COVID patients and associated with neuroinflammatory responses 6. A BRINP2-derived peptide (BRP) exhibits anti-obesity effects independent of canonical metabolic pathways 7. These findings suggest BRINP2 has pleiotropic functions beyond neural development, warranting further investigation into its broader physiological roles.