Based on limited published evidence, C15orf40 is a chromosome 15 open reading frame with predicted localization to mitochondria and cytoplasm. The gene was identified as a variant candidate in exome sequencing analysis of a family with primary failure of tooth eruption 1, though subsequent segregation analysis confirmed KMT2C as the causal gene. C15orf40 was also detected within a 15q25.2 microdeletion associated with premature ovarian failure 2, though the deletion's phenotype was attributed to other genes in the region. Specific molecular function remains undetermined.