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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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SEA
S13 erythroblastosis (avian) oncogene homolog
Chromosome 11 · 11q13
NCBI Gene: 6395
4PubMed Papers
0Diseases
0Drugs
0Pathogenic Variants
✦AI Summary

Based on the provided abstracts, there is insufficient information to write a comprehensive gene function summary for SEA (S13 erythroblastosis (avian) oncogene homolog). The only relevant abstract mentions that the SEA complex was first described in yeast Saccharomyces cerevisiae and its human homologue GATOR complex functions as an essential upstream regulator of the mTORC1 pathway 1. The abstract indicates that SEA/GATOR complex has multiple functions in nutrient response and that GATOR mutations are associated with cancer and neurodegenerative diseases 1. However, the provided abstracts do not contain sufficient detail about the specific molecular mechanisms, primary cellular functions, or clinical significance of the SEA gene to provide a complete functional summary. The remaining abstracts discuss marine biology topics unrelated to the SEA gene. Additional peer-reviewed research specifically focused on SEA gene function, protein structure, and pathological roles would be necessary to provide a comprehensive gene function summary.

Sources cited
1
SEA complex functions as essential upstream regulator of mTORC1 pathway and GATOR mutations are associated with cancer and neurodegenerative diseases
PMID: 34685669
⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
CLTCL1Protein interaction85%ACLYProtein interaction83%MRPL40Protein interaction82%ESS2Protein interaction81%DGCR2Protein interaction81%CSProtein interaction81%
Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network
Click a node to explore
SEACLTCL1ACLYMRPL40ESS2DGCR2CS
PROTEIN STRUCTURE
?
No structure data available
Structures require a reviewed Swiss-Prot entry.
RankingsWhere SEA stands among ~20K protein-coding genes
  • #18,736of 20,598
    Most Researched4
Genes detectedSEA
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
South China Sea.
PMID: 11827109
Mar Pollut Bull · 2001
1.00
2
Antioxidant Potential of Sea Cucumbers and Their Beneficial Effects on Human Health.
PMID: 36005524
Mar Drugs · 2022
0.90
3
Sperm Sensory Signaling.
PMID: 28062561
Cold Spring Harb Perspect Biol · 2017
0.80
4
The river and the sea: fieldwork in human ecology and ethnobiology.
PMID: 25277227
J Ethnobiol Ethnomed · 2014
0.70
5
Prehistoric human migration between Sundaland and South Asia was driven by sea-level rise.
PMID: 36739308
Commun Biol · 2023
0.60