C17orf75 is a component of the WDR11 complex that facilitates vesicle tethering and intracellular protein transport. Specifically, it works together with TBC1D23 to mediate golgin-dependent capture of AP-1-derived vesicles at the trans-Golgi network 1. The gene may also play a role in spermatogenesis, though detailed mechanistic evidence is limited. C17orf75 expression is regulated by the minor spliceosome component SCNM1; loss of SCNM1 function severely reduces C17orf75 expression and impairs primary cilia function and Hedgehog signaling 2. Additionally, C17orf75 expression is responsive to essential micronutrients and is downregulated in cells with impaired ZIP8 (a manganese/zinc transporter), suggesting a potential link to metal ion homeostasis 3. C17orf75 has emerged as a tumor-associated antigen (TAA) with clinical relevance: autoantibodies against C17orf75 were identified in screening for hepatocellular carcinoma (HCC) biomarkers 4, and the gene showed differential expression in retinoblastoma tissues 5. However, the functional significance of C17orf75 alterations in these cancers remains to be elucidated. The protein's role in vesicle transport and its association with ciliopathies suggest it may be important for cellular signaling and organelle function.