C1orf198 is a previously uncharacterized cytosolic protein with emerging roles in disease pathogenesis. While its precise molecular function remains undefined, C1orf198 was identified as a differentially expressed protein in ZIP8-knockout cells, suggesting potential involvement in micronutrient homeostasis pathways, though the mechanistic relationship requires further characterization 1. In human disease, C1orf198 has been identified as a novel susceptibility locus for venous thromboembolism (VTE) through genome-wide association studies, with genetic variants affecting C1orf198 expression contributing to VTE risk, potentially through effects on blood traits 2. In colorectal cancer (CRC), C1orf198 expression is significantly upregulated and correlates with advanced tumor stages and poor survival outcomes 3. Functionally, elevated C1orf198 appears associated with extracellular matrix remodeling, altered cell adhesion, and activation of oncogenic PI3K-AKT and focal adhesion pathways 3. Additionally, C1orf198 expression correlates with immune cell infiltration, M2 macrophage differentiation, and cytokine signaling (CXCL12/CXCR5), implicating its role in tumor microenvironment modulation 3. These findings identify C1orf198 as a potential prognostic biomarker in CRC and a genetic risk factor for VTE, though its specific molecular functions and mechanisms remain to be elucidated.