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2 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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C8orf44-SGK3
C8orf44-SGK3 readthrough
Chromosome 8 · 8q13.1
NCBI Gene: 100533105
14PubMed Papers
0Diseases
0Drugs
0Pathogenic Variants
✦AI Summary

Based on limited published evidence, C8orf44-SGK3 is a readthrough transcript on chromosome 8. It has been identified in genomic studies as a region subject to copy number variation in familial Parkinson's disease patients, where copy number gains were detected 1. Transcriptomic analysis shows C8orf44-SGK3 expression is altered in Porphyromonas gingivalis-infected head and neck cancer cells, clustering with genes related to cell migration 2. Specific molecular functions and cellular roles remain to be determined.

Sources cited
1
C8orf44-SGK3 copy number gains detected in familial Parkinson's disease patients; associated with CNV analysis in genes enriched in xenobiotic metabolism pathways
PMID: 40037983
2
C8orf44-SGK3 expression is dysregulated in P. gingivalis-infected head and neck cancer cells; co-expressed with migration-related genes
PMID: 38363001
⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
NEDD4LProtein interaction100%SGK1Protein interaction98%FOXO1Protein interaction96%PDPK1Protein interaction95%SGK2Protein interaction93%FOXO4Protein interaction92%
Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network
Click a node to explore
C8orf44-SGK3NEDD4LSGK1FOXO1PDPK1SGK2FOXO4
PROTEIN STRUCTURE
?
No structure data available
Structures require a reviewed Swiss-Prot entry.
RankingsWhere C8orf44-SGK3 stands among ~20K protein-coding genes
  • #15,811of 20,598
    Most Researched14
Genes detectedC8orf44-SGK3
Sources retrieved2 papers
Response time—
📄 Sources
2
1
Paired copy number variation analysis in siblings discordant for familial Parkinson's disease.
PMID: 40037983
Ann Clin Biochem · 2025
1.00
2
Transcriptomic analysis of Porphyromonas gingivalis-infected head and neck cancer cells: Identification of PLAU as a candidate prognostic biomarker.
PMID: 38363001
J Cell Mol Med · 2024
0.50