SGK2 (serum/glucocorticoid regulated kinase 2) is a serine/threonine protein kinase that regulates diverse cellular processes including ion channel activity, transporter function, and cell survival. SGK2 phosphorylates multiple substrate proteins to modulate Na+ channels (SCNN1A), K+ channels (KCNA3, KCNE1, KCNQ1), and organic anion transporters (hOAT1, hOAT4), primarily by enhancing cell surface expression and stability 12. In cancer biology, SGK2 plays critical roles in multiple malignancies. In prostate cancer, SGK2 promotes metastasis by inhibiting ferroptosis through phosphorylation of FOXO1, leading to GPX4 upregulation 3. SGK2 is overexpressed in colon cancer and promotes epithelial-mesenchymal transition 4. In ovarian cancer, SGK2 regulates platinum drug resistance by controlling autophagy through direct inhibition of the V-ATPase proton pump (ATP6V1H) 5. In lung cancer, SGK2 expression is enhanced through ac4C mRNA modification and promotes tumorigenesis by stabilizing EZH2 and suppressing autophagy-mediated cell death 6. Synthetically, SGK2 becomes essential for cell survival following p53 inactivation in cervical cancer, representing a potential therapeutic target for p53-mutant tumors 7. These findings identify SGK2 as a multifunctional oncogenic kinase with therapeutic potential across cancer types.