CAMK2G (calcium/calmodulin-dependent protein kinase II gamma) is a calcium-sensing kinase expressed predominantly in neurons and cardiomyocytes 1. In skeletal muscle, CAMK2G regulates sarcoplasmic reticulum calcium transport and controls calcium release through phosphorylation of triadin, with distinct roles in slow-twitch versus fast-twitch fibers 2. In the central nervous system, CAMK2G promotes neurite formation, dendritic spine development, and synaptic plasticity underlying long-term potentiation and hippocampus-dependent learning 3. CAMK2G functions as a calcium decoder, activating autonomously after Ca²⁺/calmodulin-binding and autophosphorylation to orchestrate cellular responses to calcium signals 1. Beyond neuronal functions, CAMK2G regulates pancreatic beta-cell insulin secretion through calcium-dependent exocytosis 4 and participates in retinal angiogenesis via the PGF2α/PTGFR/CAMK2G/p38 signaling pathway 5. Pathologically, CAMK2G variants cause intellectual developmental disorder, autosomal dominant 59 6. In cancer, CAMK2G drives cisplatin resistance in ovarian cancer by phosphorylating ITPKB to maintain redox homeostasis 7, and functions downstream of the PEAK1 pseudokinase in triple-negative breast cancer progression 8. CAMK2G inhibition represents a therapeutic strategy for platinum-resistant and triple-negative cancers.