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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
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FAM3B
FAM3 metabolism regulating signaling molecule B
Chromosome 21 Β· 21q22.3
NCBI Gene: 54097Ensembl: ENSG00000183844.18HGNC: HGNC:1253UniProt: P58499
36PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
insulin secretionprotein bindingextracellular exosomecytokine activitysinusitisovarian dysfunctionobesitycongestive heart failure
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

FAM3 metabolism regulating signaling molecule B

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
sinusitisOpen Targets
0.32Weak
ovarian dysfunctionOpen Targets
0.30Weak
obesityOpen Targets
0.17Weak
congestive heart failureOpen Targets
0.16Weak
MODYOpen Targets
0.09Suggestive
oral squamous cell carcinomaOpen Targets
0.09Suggestive
esophageal squamous cell carcinomaOpen Targets
0.09Suggestive
mathematical abilityOpen Targets
0.08Suggestive
synovium disorderOpen Targets
0.08Suggestive
metabolic syndromeOpen Targets
0.08Suggestive
type 2 diabetes mellitusOpen Targets
0.08Suggestive
type 1 diabetes mellitusOpen Targets
0.08Suggestive
diabetes mellitusOpen Targets
0.08Suggestive
neoplasmOpen Targets
0.08Suggestive
colorectal carcinomaOpen Targets
0.07Suggestive
hyperinsulinism due to glucokinase deficiencyOpen Targets
0.07Suggestive
hyperinsulinism due to INSR deficiencyOpen Targets
0.07Suggestive
osteitis deformansOpen Targets
0.06Suggestive
primary thrombocytopeniaOpen Targets
0.06Suggestive
major depressive disorderOpen Targets
0.06Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
CWC15Protein interaction91%MPLKIPProtein interaction78%CTTNBP2Protein interaction78%SNX19Shared pathway50%MAFAShared pathway50%PTPRNShared pathway25%
Tissue Expression6 tissues
Brain
100%
Lung
83%
Bone Marrow
66%
Liver
35%
Ovary
4%
Heart
0%
Gene Interaction Network
Click a node to explore
FAM3BCWC15MPLKIPCTTNBP2SNX19MAFAPTPRN
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt P58499
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.22LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.84 [0.59–1.22]
RankingsWhere FAM3B stands among ~20K protein-coding genes
  • #10,777of 20,598
    Most Researched36
  • #12,867of 17,882
    Most Constrained (LOEUF)1.22
Genes detectedFAM3B
Sources retrieved0 papers
Response timeβ€”