CARD10 encodes CARMA3, a scaffold protein essential for NF-κB pathway activation in both immune and non-immune cells 1. It functions as a core component of the CARD-BCL10-MALT1 (CBM) signalosome, which mediates receptor-dependent signaling from diverse upstream signals including G protein-coupled receptors and receptor tyrosine kinases like EGFR 2. Within CBM complexes, CARD10 nucleates BCL10-MALT1 filament assembly in a cell- and stimulus-specific manner, initiating IKK/NF-κB and JNK/AP-1 signaling cascades 3. CARD10 is also a direct transcriptional target of CEBPE and plays critical roles in granulocytic differentiation, with silencing impairing myeloid cell development 4. In endothelial cells, CARD10 suppresses angiogenesis through NF-κB activation, and lipopolysaccharide-induced miR-146a negatively regulates CARD10 expression to promote angiogenesis 5. Biallelic loss-of-function mutations in CBM complex components, including potential CARD10 defects, cause immunodeficiency with broad clinical manifestations including T and B lymphocyte defects 6. CARD10 represents a potential therapeutic target across multiple non-cancer diseases including inflammatory bowel disease, asthma, and autoimmune conditions 1.