CARD6 (caspase recruitment domain family member 6) is a multifunctional signaling protein primarily involved in regulating cell death, inflammation, and immune responses. As a CARD-containing protein, CARD6 interacts with RIP family kinases and associates with microtubules to modulate NF-κB activation 1, playing roles in both innate and adaptive immunity. CARD6 protects against hepatic ischemia/reperfusion injury by suppressing ASK1 phosphorylation and its downstream effectors JNK and p38, thereby reducing hepatocyte death and inflammation 2. In cardiac tissue, CARD6 serves as a cardioprotective factor by negatively regulating MEK kinase-1-dependent signaling, attenuating pathological hypertrophy in response to pressure overload 3. Emerging evidence demonstrates that circular CARD6 (circ-CARD6) acts as a competitive endogenous RNA, regulating oxidative stress-induced apoptosis and autophagy in retinal pigment epithelium through the miR-29b-3p/PRDX6/PI3K/Akt axis 4, and promoting posterior capsule opacification via the miR-31/FGF7 axis 5. Additionally, CARD6 is identified as a key biomarker in psoriasis and atherosclerosis pathogenesis, where it modulates immune cell activity and inflammatory responses 6. CARD6 is upregulated in gastrointestinal cancers including esophageal, gastric, and colorectal cancers, suggesting involvement in NF-κB-driven oncogenic pathways 7.