CAV3 encodes caveolin-3, a muscle-specific scaffolding protein essential for caveolae formation and muscle membrane integrity. The protein mediates recruitment of CAVIN2 and CAVIN3 proteins to caveolae and plays a critical role in sarcolemma repair mechanisms in both skeletal muscle and cardiomyocytes 1. CAV3 mutations cause a spectrum of muscle disorders collectively termed caveolinopathies, including rippling muscle disease (RMD), limb-girdle muscular dystrophy, and hyperCKemia 23. In CAV3-related RMD, the disease manifests with muscle hyperexcitability, rippling contractions, and variable phenotypes ranging from asymptomatic creatine kinase elevation to severe weakness 2. Most CAV3 mutations follow autosomal dominant inheritance, though recessive forms exist 2. Muscle biopsies from CAV3-RMD patients typically show absent or diffusely reduced caveolin-3 immunoreactivity 2. While CAV3 mutations are associated with various neuromuscular phenotypes including hyperCKemia and limb-girdle muscular dystrophy, studies have not consistently demonstrated involvement in cardiomyopathies 3. The protein's role in membrane repair and caveolae assembly makes it crucial for maintaining muscle fiber integrity under mechanical stress.