CCDC25 (coiled-coil domain containing 25) functions as a transmembrane receptor that specifically recognizes extracellular DNA from neutrophil extracellular traps (NETs) and eosinophil extracellular traps (EETs) 12. Upon binding NET-DNA, particularly 8-OHdG-enriched DNA, CCDC25 activates the ILK-PARVB signaling pathway, leading to cytoskeletal rearrangement and enhanced cell motility 1. In cancer contexts, CCDC25 promotes metastasis by sensing NETs and facilitating tumor cell migration, with high expression associated with poor prognosis in breast, colon, and esophageal cancers 13. The protein also mediates therapeutic resistance by inducing epithelial-mesenchymal transition through pyruvate kinase M2-mediated STAT3 phosphorylation 4. In cardiovascular disease, CCDC25 contributes to doxorubicin cardiotoxicity by recognizing NET-DNA and activating autophagic flux 5. Additionally, CCDC25 plays roles in allergic asthma by activating pulmonary neuroendocrine cells 2, wound healing through fibroblast proliferation 6, and autoimmune diseases like bullous pemphigoid by promoting T follicular helper cell differentiation 7. Genome-wide association studies have identified CCDC25 as a susceptibility locus for giant cell arteritis 8.