CCDC85C is a coiled-coil domain-containing protein functioning primarily in cell-cell adhesion and cortical development through interactions with catenin family proteins. At the molecular level, CCDC85C binds to GSK-3β and p120-catenin isoforms, modulating β-catenin stability and adherens junction dynamics 12. The protein localizes to apical junctions of radial glia during neural development 3. In disease contexts, CCDC85C dysregulation is implicated in multiple cancers. In colorectal cancer, CCDC85C overexpression suppresses proliferation and migration by promoting β-catenin degradation 1, and constitutes a prognostic marker modulated by therapeutic interventions 4. In hepatocellular carcinoma, CCDC85C activates β-catenin signaling downstream of the KLF7/VPS35 axis, promoting cell progression 5. Additionally, CCDC85C participates in centrosome amplification triggered by cadmium exposure via the ROS-GCLM pathway, potentially linking environmental toxins to cancer initiation 6. Genetically, CCDC85C mutations cause hemorrhagic hydrocephalus and cortical heterotopia in mice through disruption of radial glial maintenance 3, and genetic variants associate with Alzheimer's disease survival 7. CCDC85C is also connected to ulcerative colitis-associated colorectal cancer progression through miRNA regulatory networks 8.