CCL24 (eotaxin-2) is a pro-inflammatory and pro-fibrotic chemokine that primarily functions to recruit eosinophils and resting T-lymphocytes through CCR3 receptor binding 12. The protein demonstrates chemotactic activity for eosinophils and resting T-lymphocytes while showing lower activity for neutrophils and no activity for monocytes or activated lymphocytes 1. CCL24 operates through multiple pathways including the Piezo1-Wnt2/Wnt11-CCL24 positive feedback loop in mechanical stress responses 3. In disease contexts, CCL24 plays significant roles in fibrotic disorders, being highly expressed in primary sclerosing cholangitis (PSC) where it regulates biliary inflammation and fibrosis 1. Elevated CCL24 levels correlate with Enhanced Liver Fibrosis scores in PSC patients 1. The chemokine is also involved in skin fibrosis progression through mechanotransduction pathways 3 and contributes to asthma pathogenesis by mediating eosinophil recruitment in type 2 inflammatory responses 4. Therapeutically, CCL24 represents a promising target, with neutralizing antibodies showing beneficial effects in experimental models of fibrotic diseases 1. Additionally, GPR182/ACKR5 functions as a scavenging receptor for CCL24, regulating its spatial distribution 2.