CCR10 is a G protein-coupled chemokine receptor that plays crucial roles in epithelial immunity and tissue-specific immune cell homing. The receptor binds to chemokines CCL27 and CCL28, mediating chemotaxis and calcium signaling 1. CCR10 functions primarily in two distinct anatomical contexts: skin immunity, where it responds to CCL27 produced by keratinocytes to recruit CCR10+ T cells, and mucosal immunity, where it responds to CCL28 from mucosal epithelial cells to recruit IgA+ plasma cells 12. In cancer contexts, CCR10-CCL28 signaling facilitates recruitment of regulatory T cells to tumor microenvironments, contributing to immunosuppression 3. The receptor also mediates IgA+ plasma cell recruitment in colorectal cancer liver metastases and promotes B cell migration within tertiary lymphoid structures 45. Additionally, CCR10 enables bone marrow-derived immune cells to invade the CNS in Alzheimer's disease, exacerbating neurodegeneration 6. Clinical significance includes its potential impairment in psoriasis due to decreased CCL27 expression 7 and its role as a therapeutic target in cancer immunotherapy and neurodegenerative diseases.