CCR2 (C-C motif chemokine receptor 2) is a chemokine receptor that plays a critical role in inflammatory cell recruitment and tissue homeostasis. The primary function of CCR2 is to mediate monocyte/macrophage trafficking through binding to its ligands, particularly CCL2 1. CCR2 is expressed on inflammatory monocyte subsets (CX3CR1lo CCR2+ Gr1+) that are actively recruited to inflamed tissues, distinguishing them from tissue-resident macrophage populations 12. The CCL2-CCR2 axis mediates multiple pathological processes including cardiovascular disease, where CCR2+ macrophages contribute to pulmonary hypertension through crosstalk with smooth muscle cells 3 and atherosclerosis development 4. In cancer, CCR2 signaling promotes tumor progression by recruiting immunosuppressive macrophages and facilitating metastasis 56. CCR2 is also essential for joint inflammation in osteoarthritis, where CCL2/CCR2-mediated monocyte recruitment drives cartilage destruction 7. The receptor's significance extends to clinical applications, as CCR2+ macrophage abundance correlates with cardiac dysfunction in heart failure patients 2, and CCL2 expression serves as a prognostic marker in hepatocellular carcinoma 6. Therapeutically, dual CCR2/CCR5 targeting shows promise for treating multiple inflammatory diseases 3.