CD36 is a multifunctional transmembrane scavenger receptor that serves as the primary mediator of long-chain fatty acid uptake across cell membranes 1. Beyond lipid transport, CD36 binds diverse ligands including thrombospondin-1, apoptotic cells, and pathogen-associated molecular patterns, enabling roles in inflammation, immunological recognition, and molecular adhesion 2. CD36 functions as a critical fatty acid sensor that coordinates fat utilization through oral fat perception, intestinal absorption, and regulation of hepatic lipoprotein output 3. In cardiovascular disease, CD36 expression is dysregulated across multiple pathologies: decreased in ischaemia-reperfusion injury but increased in diabetic cardiomyopathy and atherosclerosis 1. CD36 also plays complex roles in liver pathophysiology, participating in lipid metabolism, inflammation, and oxidative stress relevant to fatty liver disease, NASH, fibrosis, and hepatic malignancy 4. CD36 has emerged as a significant oncologic target. In cancer, CD36-driven lipid metabolic reprogramming promotes metastatic initiation and therapy resistance, with metastasis-initiating cells showing high CD36 expression enhanced by dietary palmitic acid 5. In the tumor microenvironment, CD36-mediated fatty acid uptake by CD8+ T cells induces ferroptosis and immunotolerance, while CD36 inhibition restores antitumor immunity 6. Recent evidence identifies CD36 as a downstream target in colorectal cancer progression via the PLIN2/CD36 axis regulating epithelial-mesenchymal transition 7.