CDC37L1 is an HSP90 co-chaperone located on chromosome 9 that functions as a molecular adapter promoting client protein interactions with heat shock proteins Hsp70 and Hsp90 1. As a co-chaperone family member of CDC37, CDC37L1 participates in protein folding and stabilization through binding to unfolded proteins and heat shock proteins in the cytosol 1. A novel role for CDC37L1 has been identified in tau regulation, where it likely contributes to proper folding, degradation, and recycling of tau proteins and tau kinases in neurodegenerative disease pathways 1. CDC37L1 has emerged as a significant gene in chromosome 9 deletion syndrome, identified as important for the majority (83%) of affected individuals through whole-genome sequencing analysis 23. Clinically, anti-CDC37L1 autoantibodies serve as biomarkers for hepatocellular carcinoma detection, with CDC37L1-targeting antibodies showing utility in early HCC diagnosis and in identifying AFP-negative cases 45. Additionally, CDC37L1 expression is significantly reduced in nasopharyngeal carcinoma compared to normal tissue 6, suggesting potential tumor suppressor functions. CDC37L1 has been associated with idiopathic dilated cardiomyopathy progression, indicating broader relevance in cardiac pathology 7.