CDCA4 (cell division cycle associated 4) is a nuclear protein that plays a critical role in cell cycle regulation and proliferation control. The protein contains a SERTA domain and exhibits nuclear localization throughout all cell cycle phases 1. CDCA4 functions as an oncogenic factor that promotes cell proliferation through multiple mechanisms, including regulation of the PI3K/AKT pathway by reducing PTEN expression and increasing p-PI3K and p-AKT levels 2. The protein also interacts with IGF2BP1 to regulate lung adenocarcinoma proliferation 2. CDCA4 is subject to ubiquitin-independent proteasomal degradation via C-degron pathways, suggesting tight regulatory control of its levels 3. In cancer contexts, CDCA4 is widely overexpressed across multiple tumor types and associated with poor overall survival and disease-free survival 4. The protein enhances proliferation and reduces apoptosis in breast cancer cells 5, and its knockdown induces cellular senescence markers 6. CDCA4 expression correlates with tumor immune infiltration and is associated with radiotherapy resistance in colorectal cancer 7. The protein is directly targeted by miR-15a, which suppresses melanoma growth and invasiveness 8. During development, CDCA4 shows spatiotemporally restricted expression in various tissues including facial primordia, limb buds, and neural structures 1.