CDH13 encodes T-cadherin, an atypical glycosyl-phosphatidylinositol-anchored cadherin functioning as a calcium-dependent cell adhesion molecule with pleiotropic roles across neurodevelopmental, metabolic, and cardiovascular systems 1. Structurally, CDH13 mediates homophilic cell-cell adhesion and serves dual roles as a metabolic receptor for adiponectin and low-density lipoprotein 1. In the nervous system, CDH13 regulates neurite outgrowth, axon guidance, and brain network development and plasticity 2. Genetically, CDH13 variants are replicably associated with ADHD and related neuropsychiatric conditions 2, with polymorphisms influencing substance use disorder susceptibility and reward sensitivity 3. Metabolically, CDH13 genetic variants contribute to circulating adiponectin levels and are associated with metabolic syndrome risk, particularly the rs3865188 AT genotype in diverse populations 45. CDH13 expression is regulated by multiple non-coding RNAs including miR-199b-5p, miR-377-3p, and lncRNAs, creating regulatory networks affecting cardiovascular and metabolic phenotypes 1. Clinically, CDH13 gene methylation status predicts treatment response in endometrial cancer and associates with liver cancer incidence, correlating with smoking and alcohol exposure 67.