CDH24 (cadherin-24) is a type II cadherin that mediates calcium-dependent cell-cell adhesion through homophilic interactions 1. The protein contains five extracellular calcium-binding repeat domains, a transmembrane domain, and a cytoplasmic domain that associates with α-catenin, β-catenin, and p120 catenin 1. CDH24 undergoes alternative splicing in extracellular repeat 4, producing both 781 and 819-amino acid isoforms, both capable of strong cell-cell adhesion 1. The protein facilitates direct cell-cell interactions and promotes cell aggregation, contributing to morphogenesis and partial cell polarization 2. CDH24 exhibits dysregulated expression across multiple cancers. It is upregulated in lung adenocarcinoma and serves as an independent prognostic biomarker 3. In gastric cancer, CDH24 is significantly elevated and associated with altered survival outcomes 4. CDH24 harbors frameshift mutations in gastric and colorectal cancers with high microsatellite instability, potentially inactivating its adhesion functions 5. Additionally, CDH24 was identified as an imprinted gene with age-related DNA methylation alterations in paternal sperm associated with autism spectrum disorder risk in offspring 6. In rectal cancer, CDH24 methylation patterns may predict radiochemotherapy response 7. CDH24 expression was also differentially regulated in psoriasis-discordant monozygotic twins 8.