CDH8 (cadherin 8) is a calcium-dependent cell adhesion protein that mediates homophilic cell-cell adhesion through interactions with catenin complexes at adherens junctions 1. In the developing brain, CDH8 exhibits spatiotemporal expression enriched in cortex, hippocampus, and thalamus/striatum during peak synaptogenesis and associates with excitatory synaptic markers 2. CDH8 plays critical roles in neural circuit development, including axon terminal field positioning and restraint in corticostriatal projections; loss of CDH8 in prefrontal cortex neurons causes ventral shifting of striatal axon terminals and impairs action-outcome learning 3. Type II cadherins including CDH8 regulate neural tube compartmentalization and neurulation through redundant adhesive codes; combined CDH8 knockout with other cadherins results in exencephaly and neuroepithelial abnormalities 4. CDH8 variants are implicated in neurodevelopmental disorders, particularly autism spectrum disorder and attention-deficit/hyperactivity disorder, identified through genome-wide association studies 51. Additionally, CDH8 promoter hypermethylation correlates with cervical cancer progression and serves as a biomarker component in cervical cytology classification 67. CDH8 expression is upregulated in autism-derived induced pluripotent stem cell-derived neural precursor cells 2, suggesting altered cadherin-mediated signaling in neurodevelopmental pathology.