CEBPG (CCAAT enhancer binding protein gamma) is a sequence-specific DNA-binding transcription factor that regulates gene expression across multiple biological processes. CEBPG functions as both a transcriptional activator and corepressor, binding to CCAAT elements and other regulatory sequences in target gene promoters and enhancers 1. It forms heterodimeric complexes with other transcription factors like ATF4 to regulate target genes 2. In disease contexts, CEBPG plays significant roles in cancer progression and metabolic stress responses. CEBPG suppresses ferroptosis in ovarian cancer by transcriptionally activating SLC7A11, a key ferroptosis inhibitor, and elevated CEBPG expression correlates with poor prognosis 3. In nasopharyngeal carcinoma, CEBPG mRNA stability is enhanced through ac4C acetylation, promoting immunosuppression and T-cell dysfunction 4. CEBPG also regulates DNA repair gene ERCC5 expression in bronchial epithelial cells, with polymorphisms potentially contributing to lung cancer risk 1. Additionally, CEBPG acts as a key transcriptional regulator in dedifferentiated cardiomyocytes during atrial fibrillation remodeling 5, and serves as a critical transcription factor in mesenchymal glioblastoma 6. CEBPG participates in protective responses against lipotoxicity by co-regulating RETREG1-mediated reticulophagy 2 and regulates CCR2 transcription in bladder cancer development 7.