CENPN (centromere protein N) is a critical component of the CENPA-NAC complex essential for centromere assembly and chromosome 16 1. As the first protein to bind specifically to CENPA nucleosomes, CENPN directly facilitates kinetochore protein assembly and mitotic chromosome 16 1. Beyond its canonical centromeric role, CENPN exhibits oncogenic functions across multiple cancer types, with elevated expression correlating with poor prognosis in nasopharyngeal carcinoma, breast cancer, and lung adenocarcinoma 234. In nasopharyngeal carcinoma, CENPN suppresses autophagy via the CREB-VAMP8 signaling axis, promoting paclitaxel resistance 5, while simultaneously promoting invasion and metastasis through the CENPN/STAT3/USP37 signaling axis 6. In lung adenocarcinoma, CENPN activates PI3K/AKT signaling to enhance cell viability, stemness, and invasiveness 3. Pan-cancer analyses reveal CENPN upregulation across diverse malignancies with correlation to immune cell infiltration patterns and potential utility as a prognostic biomarker 47. CENPN represents both a fundamental centromeric protein required for faithful genome propagation and an emerging oncogenic target for therapeutic intervention across multiple cancer types.