ITGB3BP (integrin subunit beta 3 binding protein) is a multifunctional protein that serves as a transcriptional coregulator and cell cycle modulator with significant roles in cancer biology and cellular development. The protein functions as both a coactivator and corepressor for various nuclear receptors, including retinoid X receptors and thyroid hormone receptors in a ligand-dependent manner 1. ITGB3BP acts as a component of the CENPA-CAD complex involved in chromosome 1 and kinetochore protein assembly during mitosis 2. In cancer contexts, ITGB3BP expression is associated with poor prognosis across multiple tumor types. High expression correlates with poor outcomes in glioma patients and activates tumor-related signaling pathways 3. In ovarian cancer, ITGB3BP suppression increases the proportion of malignant side population cells through hedgehog pathway activation 4. The protein also modulates chemotherapy resistance in bladder cancer, where its interaction with ARF impairs protein translation and contributes to cisplatin resistance 5. Additionally, ITGB3BP regulates cellular migration and is predictive of metastasis-free survival in breast cancer patients 6. Recent studies indicate ITGB3BP undergoes MDM2-mediated ubiquitination and degradation, affecting osteogenic differentiation and mitochondrial function in stem cells 7.