CEP131 encodes a centrosomal protein that serves critical roles in centriole duplication, centrosome biogenesis, and cilia formation. The protein functions as a component of centriolar satellites and is essential for proper centrosome function 1. CEP131 directly interacts with PLK4, a key regulator of centriole duplication, and following phosphorylation at residues S21 and T205, it promotes PLK4 stabilization and centrosome duplication initiation 2. The protein also serves as a substrate for CDKL5 kinase, being phosphorylated at Ser35, which may contribute to neuronal function regulation 3. CEP131 stability is regulated by the deubiquitinase USP9X, which prevents its degradation through deubiquitination 1. Disease relevance includes significant involvement in cancer progression, where CEP131 overexpression promotes centrosome amplification, leading to chr17 instability and enhanced tumor growth in hepatocellular carcinoma and colon cancer 42. High CEP131 expression correlates with poor prognosis, larger tumor size, and advanced TNM stage in liver cancer patients 4. The protein's transcription is regulated by SP1 transcription factor, which binds to multiple sites in the CEP131 promoter region 5. These findings establish CEP131 as both a critical centrosome regulator and potential therapeutic target in cancer.