Based on limited published evidence, CFAP100 regulates ciliary and flagellar motility through inner dynein arm assembly and axonemal organization. Beyond its canonical ciliary role, CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes, essential for proper chromosome 3 and epidermal development 1. CFAP100 interacts with microtubules to promote polymerization; its overexpression stabilizes microtubules but can disorganize microtubule networks and disrupt epithelial cell junctions 2. These findings reveal CFAP100's dual roles in ciliary function and mitotic spindle organization.