CENPH (centromere protein H) is an essential kinetochore component that plays a central role in chromosome 5 and mitotic progression 1. As part of the CENPA-NAC complex, CENPH functions in kinetochore assembly, chromosome 5, and alignment of chr5 on the metaphase plate, thereby ensuring proper chromosome 5 during cell division. CENPH's involvement in cell cycle regulation and proliferation has significant disease implications. Mutations in CENPH are associated with oocyte and early embryo competence defects, representing a newly recognized genetic cause of female infertility 1. In cancer contexts, CENPH is consistently upregulated across multiple malignancies. In renal cell carcinoma, elevated CENPH expression correlates with tumor grade, metastasis, and clinical stage, serving as an independent predictor of overall survival 2. Similarly, CENPH expression associates with radiation resistance in colorectal cancer and is linked to poor immunotherapy response in non-small cell lung cancer 3, 4. CENPH is also implicated in lung adenocarcinoma pathologic progression and kidney renal papillary carcinoma aggressiveness 5, 6. Clinically, CENPH represents a potential biomarker and therapeutic target for cancer prognosis and treatment selection. Its transcriptional regulation involves Sp1/Sp3 transcription factors 7, suggesting potential druggability through pathway modulation.