CHMP1A is a peripheral component of the ESCRT-III complex involved in multivesicular body (MVB) formation and endosomal cargo sorting 1. It mediates trafficking of ubiquitinylated proteins to lysosomes for degradation and functions in membrane fission events including cytokinesis and viral budding 2. CHMP1A is recruited to autophagosomes during mitophagy, where it facilitates phagophore closure alongside VPS4A 2. Beyond canonical ESCRT functions, CHMP1A participates in Rab11a-exosome biogenesis in recycling endosomes, particularly under nutrient stress 3. Clinically, CHMP1A functions as a tumor suppressor across multiple cancer types. In pancreatic ductal tumor cells, CHMP1A overexpression inhibits cell growth through p53-dependent mechanisms 1. In renal cell carcinoma, CHMP1A suppresses tumor growth via the PI3K/mTOR/p53 signaling pathway 4. CHMP1A is also implicated in neurodegenerative disease: genetic variants in CHMP1A have been identified in late-onset Parkinson's disease families with predicted pathogenic effects 56. Additionally, CHMP1A dysregulation is associated with fibrotic complications in Crohn's disease 7. Disease-associated mutations in CHMP1A cause pontocerebellar hypoplasia 8, highlighting its essential developmental role.