CHODL (chondrolectin) is a type I transmembrane protein containing a C-type lectin carbohydrate recognition domain that plays crucial roles in neuromuscular development and cancer progression 1. The protein is predominantly expressed in skeletal muscle, heart, testis, brain, and lung tissues, with particularly high expression during embryonic development in muscle cells of heterogeneous origin 2. CHODL functions in motor neuron development by facilitating axon extension and neuromuscular junction formation through its interaction with muscle-derived collagen XIXa1 via its extracellular lectin domain 3. The protein's cytoplasmic domain interacts with Rab geranylgeranyl transferase beta-subunit, suggesting involvement in intracellular trafficking pathways 4. In cancer, CHODL exhibits tissue-specific roles: it acts as a tumor suppressor in colorectal cancer where promoter hypermethylation silences its expression and correlates with poor prognosis 5, while in lung cancer, CHODL overexpression promotes cell growth and invasion, serving as both a diagnostic biomarker and therapeutic target 6. The protein undergoes N-glycosylation and shows predominantly perinuclear localization in transfected cells 1. CHODL represents an evolutionarily conserved factor critical for proper neuromuscular synaptogenesis and exhibits complex, context-dependent roles in cancer pathogenesis.