ITGB1BP2 (melusin) is a muscle-specific signaling protein that plays a role in myocyte maturation and organization 1. The protein functions as an integrin β1-binding partner involved in mechanotransduction and integrin signaling pathways 2. In cardiac tissue, melusin is required for compensatory hypertrophy response in pressure-overloaded hearts 1. ITGB1BP2 also regulates integrin β1D isoform expression and myoblast fusion through interactions with CD9 and FRZB, functioning as a negative regulator of FRZB expression 3. In disease contexts, ITGB1BP2 variants have been investigated in hypertensive and cardiomyopathic patients, though genetic screening of nearly 1000 subjects revealed extremely low mutation prevalence, suggesting high conservation of the melusin gene 1. A missense mutation (c.938C>G) was identified in a dilated cardiomyopathy patient, though its functional significance remains unclear 4. Beyond cardiac pathology, elevated ITGB1BP2 levels serve as a biomarker associated with symptomatic carotid stenosis 5, cervical cancer 6, and atopic dermatitis with cardiovascular disease associations 7. These findings suggest ITGB1BP2 functions in integrin-mediated signaling across multiple tissues and may contribute to various cardiovascular and systemic pathologies.