SAC3D1 (SAC3 domain containing 1) is a centrosome-associated protein involved in cell cycle regulation and genomic stability. Located on chromosome 11, SAC3D1 functions as a protein binding partner at the centrosome and spindle apparatus, playing roles in centrosome duplication and spindle assembly 1. Mechanistically, SAC3D1 activates oncogenic Wnt/β-catenin signaling by interacting with axin and inhibiting β-catenin ubiquitination, thereby elevating β-catenin protein levels 2. SAC3D1 is significantly upregulated across multiple cancer types including hepatocellular carcinoma, gastric cancer, and osteosarcoma, where elevated expression correlates with poor prognosis, advanced clinicopathologic features, and tumor progression 345. In osteosarcoma and hepatocellular carcinoma, SAC3D1 promotes malignant behaviors including proliferation, migration, and invasion, while its knockdown inhibits these processes 5. SAC3D1 expression is associated with cell cycle acceleration, immunosuppressive microenvironments, and reduced immunotherapy response 1. Beyond cancer, SAC3D1 harbors genetic variants associated with susceptibility to chr11 Chagas cardiomyopathy development, with functional evidence suggesting DNA methylation-dependent regulation of SAC3D1 expression influences cardiovascular outcomes 67. These findings position SAC3D1 as a promising prognostic biomarker and therapeutic target across multiple disease contexts.