CINP — cyclin dependent kinase 2 interacting protein

15 sources retrieved · Most recent: April 2026 · Index updated 22 days ago

28PubMed Papers

#12,372 · top 64% of 19K genes

20Diseases

top 66%

0Drugs

1Pathogenic Variants

top 96%

DNA RepairExperimental GO EvidenceSwiss-Prot Reviewed

protein bindingpreribosome bindingDNA replicationribosomal large subunit biogenesisneurodegenerative diseasemicrocephalySeizureIntellectual disability

AI Summary

Insufficient information available. None of the provided PubMed abstracts contain data about CINP (cyclin dependent kinase 2 interacting protein) or its molecular functions. The abstracts focus on unrelated clinical topics including psychiatric treatments, pain management, and therapeutic interventions, but do not discuss CINP's role in DNA replication, cell cycle regulation, or chr14 biology.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

neurodegenerative diseaseOpen Targets

0.50Moderate

microcephalyOpen Targets

0.27Weak

Intellectual disabilityOpen Targets

0.27Weak

SeizureOpen Targets

0.27Weak

hereditary spastic paraplegiaOpen Targets

0.12Weak

allergic rhinitisOpen Targets

0.06Suggestive

MODYOpen Targets

0.06Suggestive

brain cancerOpen Targets

0.05Suggestive

nervous system cancerOpen Targets

0.05Suggestive

maturity-onset diabetes of the young type 3Open Targets

0.05Suggestive

maturity-onset diabetes of the young type 10Open Targets

0.04Suggestive

hyperproinsulinemiaOpen Targets

0.04Suggestive

Glycogen storage disease due to hepatic glycogen synthase deficiencyOpen Targets

0.04Suggestive

glycogen storage disorder due to hepatic glycogen synthase deficiencyOpen Targets

0.04Suggestive

neoplasmOpen Targets

0.02Suggestive

DNA methylationOpen Targets

0.02Suggestive

small cell lung carcinomaOpen Targets

0.01Suggestive

cervical squamous cell carcinomaOpen Targets

0.01Suggestive

lung adenocarcinomaOpen Targets

0.01Suggestive

pancreatic adenocarcinomaOpen Targets

0.01Suggestive

Pathogenic Variants1

NM_032630.3(CINP):c.637T>G (p.Ter213Gly)Likely pathogenic

Intellectual disability;Seizure;Microcephaly

★☆☆☆→ Residue 213

Tissue Expression6 tissues

Brain

100%

Heart

93%

Liver

72%

Bone Marrow

66%

Lung

46%

Ovary

43%

Gene Interaction Network6 neighbors

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Structure3 PDB hits

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PDB8CIH · 2.00 Å · X-ray

View on RCSB

ConstraintgnomAD v4.1

LOEUFⓘ

0.78LoF Tolerant

pLIⓘ

0.11Tolerant

Observed/Expected LoF0.46 [0.28–0.78]

Rankings3 dim

Where CINP stands among ~20K protein-coding genes

#12,331of 20,598
Most Researched28
#5,276of 5,499
Most Pathogenic Variants1
#6,351of 17,882
Most Constrained (LOEUF)0.78