Based on limited published evidence, TMA16 is involved in biogenesis of the 60S ribosomal subunit in the nucleus. It functions in preribosome binding and protein-macromolecule adaptor activity within the nucleolus, nucleoplasm, and nucleus. Structural analysis revealed TMA16 localized between the 5S RNA and P0 stalk in human pre-60S particles before nuclear export, suggesting a role in pre-ribosomal particle maturation 1. Additionally, TMA16 methylation patterns in cell-free DNA have been identified as a potential diagnostic marker for Parkinson's disease 2.